ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: Diabetes Care. 2018;41:128-135Renal damage and kidney failure are amongst the most detrimental co-morbidities of T1DM. In order to be able to prevent renal disease in the first place and treat progression of diabetic renal disease to kidney failure, the mechanisms that lead from high blood glucose levels to damage of the vascular bed of the glomerulus and to end stage renal...

Brief summary: MiTy Kids is a prospective cohort study of children who were exposed to metformin during pregnancy. At 24 months, no difference was observed between those exposed to metformin and a placebo group, in BMI trajectories, mean BMI Z-score, or mean sum of skinfolds. Among those exposed to metformin, the BMI was higher among males than females.Comment: Metformin is increasingly used during pregnancy in women with T2D, but data on its lo...